Description
Semax is the seven-residue peptide Met-Glu-His-Phe-Pro-Gly-Pro, commonly written ACTH(4-7)PGP. It combines the ACTH(4-7) fragment with a Pro-Gly-Pro tail and is distinct from full-length ACTH.
The literature is centred on cellular and animal models of cerebral ischaemia, neurotrophic signalling and changes in brain gene or protein expression. Internationally available, independently replicated human evidence is comparatively limited.

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